Intact vesicles are MOST likely to be seen in which condition?

• A. Herpes simplex infection
• B. Oral lichenoid reaction
• C. Aphthous ulceration
• D. Cicatricial pemphigoid

Answer: (D)

Intact vesicles are most commonly associated with cicatricial pemphigoid, a chronic autoimmune condition that affects the mucous membranes and skin. In this condition, the immune system attacks the basement membrane components, leading to the formation of blisters (vesicles) that can remain intact for a period of time before rupturing. The presence of these intact vesicles is a hallmark sign of cicatricial pemphigoid.

In contrast, other conditions present different clinical features and manifestations. Herpes simplex infection tends to present with vesicles that quickly rupture and form ulcers, rather than remaining intact. Oral lichenoid reactions and aphthous ulceration typically involve erosive lesions or ulcers rather than intact vesicles, further indicating that cicatricial pemphigoid is the correct choice for identifying intact vesicles in a clinical context.